Marker genome maps of the sheep and goat
نویسنده
چکیده
The organisation of the domestic bovid genomes is very similar, thus ovine and caprine genome mapping may benefit from the most advanced bovine map. At present, there have been identified over 2000 markers in the sheep and over 700 in the goat. Recently, several spectacular examples of the genome map application for the identification of loci controlling important traits have been reported, for instance: muscular hypertrophy and high fecundity in the sheep, and polled intersex syndrome in the goat. Searching for genes controlling other traits (resistance to gastro-intestinal parasites, wool quality, milk productivity, etc.) is performed with the use of the genome scanning approach, which is based on advanced genome maps. Also other molecular tools, such as species-specific sheep and goat genome libraries cloned in bacterial artificial chromosomes (BACs) and cDNA libraries, bring an opportunity for a detailed study of the sheep and goat study. In the near future another important tool – the cattle genome sequence – will also be available.
منابع مشابه
An enhanced linkage map of the sheep genome comprising more than 1000 loci.
A medium-density linkage map of the ovine genome has been developed. Marker data for 550 new loci were generated and merged with the previous sheep linkage map. The new map comprises 1093 markers representing 1062 unique loci (941 anonymous loci, 121 genes) and spans 3500 cM (sex-averaged) for the autosomes and 132 cM (female) on the X chromosome. There is an average spacing of 3.4 cM between a...
متن کاملFISH-mapping of LEP and SLC26A2 genes in sheep, goat and cattle R-banded chromosomes: comparison between bovine, ovine and caprine chromosome 4 (BTA4/OAR4/CHI4) and human chromosome 7 (HSA7).
Sheep (OAR), goat (CHI) and cattle (BTA) R-banded chromosome preparations, obtained from synchronized cell cultures, were used to FISH-map leptin (LEP) and solute carrier family 26 member 2 (SLC26A2) genes on single chromosome bands. LEP maps on OAR4q32 and CHI4q32, being the first assignment of this gene to these two species. SLC26A2 maps on BTA7q24, OAR5q24 and CHI7q24. This gene, too, was as...
متن کاملSingle Nucleotide Polymorphism Analysis of the Bone Morphogenetic Protein Receptor IB and Growth and Differentiation Factor 9 Genes in Rayini Goats (Capra hircus)
The FecB, a mutation in the bone morphogenetic protein receptor IB (BMPR-IB) gene, which increases the fecundity of Booroola Merino sheep, and FecGH, a mutation in the Growth and Differentiation Factor 9 (GDF9), which affects the fecundity of Cambridge and Belclare sheep in a dose sensitive manner, were analyzed as candidate genes associated with the prolificacy in Rayini goats. These polymorph...
متن کاملAn advanced sheep (Ovis aries, 2n = 54) cytogenetic map and assignment of 88 new autosomal loci by fluorescence in situ hybridization and R-banding
Presented herein is an updated sheep cytogenetic map that contains 452 loci (291 type I and 161 type II) assigned to specific chromosome bands or regions on standard R-banded ideograms. This map, which significantly extends our knowledge of the physical organization of the ovine genome, includes new assignments for 88 autosomal loci, including 74 type I loci (known genes) and 14 type II loci (S...
متن کاملDetection of Toxoplasma gondii in sheep and goats blood samples by PCR-RFLP in Urmia
Infection by the protozoan parasite Toxoplasma gondii, is widespread in humans and many other warm-blooded animals. More than half billion of world human population has serum antibodies to T. gondii and Sheep and goats are more widely infected with T. gondii. T. gondii infection can be diagnosed indirectly with serological methods and directly by pol...
متن کامل